The Beatrice Bugle

~  3/13/2019 ~ 

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Drugs that have been documented to cause problems in collies include:




Vincristine Vinblastine Doxorubicin

Ivermectin,  Heartguard

Loperamide – (Imodium) At doses used to treat diarrhea.

Selamectin, milbemycin, and moxidectin (antiparasitic agents) 

Spinosad, a flea-control medication included in 



     Vethical AcuGuard and ComboGuard






Please only give your collie: Interceptor® Plus‎, Interceptor, or Sentinel. This is so important, because many veterinarians have been telling collie buyers there is only a small amount of ivermectin or spinosad (flea med) in heartworm pills that it should be quite safe. This is not the case! There can be a toxic reaction that allows the ivermectin to pass the dog's blood-brain barrier and into its central nervous system, which can be lethal for the animal.

Symptoms for the dog may be acute or mild. Acute signs will become apparent within 4 to 12 hours of the drug's administration. In mild cases, symptoms will occur between 48 to 96 hours after your dog has been treated. Such symptoms include: 


  • Lethargy

  • Depression

  • Drooling

  • Vomiting

  • Dilation of the pupil

  • Loss of appetite (anorexia)

  • Difficulty controlling voluntary movement

  • Disorientation

  • Tremors/Seizures

  • Inability to stand

  • Blindness

  • Slow heartbeat

  • Respiratory distress

  • Coma








Drug Sensitivity